Cant help you when it comes to macs. I think Apple virtually shove an i in front of all its devices. this said, they promote thier own products mostly to be used with macs. There you can be guaranteed total compatibility.
I shouldnt think a standard usb device for mass storage will be unrecognised by a mac.
As for iTunes - i dont know. my music collection was aquired via other means, so i have no use for such programs
Peace
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